Single-cell RNA sequencing unveils the activation of EGR1-ATF3 signaling in EGR1 + muscle stem cells during human paravertebral muscle degeneration
Background: Paravertebral muscles (PVM) degeneration (PMD) is closely associated with low back pain.Muscle stem cells (MuSCs) can promote muscle regeneration and repair.However, our understanding of the cellular composition of PVM and the key genes-mediated MuSCs functions is limited.Methods: We analyzed cells heterogeneity and identified key genes